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SENNA

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Senna is a laxative used for short-term treatment of constipation. It is available as nonprescription drugs and as herbal products.

Safetychecker Summary for Senna
(for details about the summarized interactions, read the full article)

Check Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.

Digitalis

Potassium

Sodium

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

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Interactions with Dietary Supplements

Sodium and potassium
Overuse or misuse of laxatives, including senna, can cause water, sodium, and potassium depletion.1 To avoid depletion problems, people should limit laxative use, including senna, to one week or less.2

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Interactions with Herbs

Digitalis (Digitalis lanata, Digitalis purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin. While the interaction has not been reported, overuse or misuse of senna (leading to potassium loss) may increase digitalis effects and risk of side effects.3 Senna and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.

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References: Top

1. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 318a–9.

2. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 318a–9

3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Healthcare Professionals. London: Pharmaceutical Press, 1996, 244.

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